Reduction of emissions and improvement of efficiency are two important issues in internal combustion engine research. The use of biomass-derived fuels in Diesel engines offers a good solution to reduce well-to-wheels (WTW) greenhouse gas (GHG) emissions. Partially premixed combustion (PPC) has shown the potential of high efficiency combined with low soot and NOx emissions. The objective of this study was to investigate the effect of using alcohol/Diesel blends or neat alcohols on emissions and thermal efficiency for PPC combustion. In the current study, four different alcohols were selected, i.e. n-butanol, isobutanol, n-octanol and 2-ethylhexanol. The alcohols were blended with fossil Diesel fuel to low a cetane number (CN) to around 26 or 36 suitable for PPC combustion. The fuel blends were tested in a single cylinder light duty (LD) engine. To optimize combustion exhaust gas recirculation (EGR) level, injection strategy was tuned. The measured emissions and thermal efficiency from PPC combustion were compared with that obtained from conventional combustion with production engine settings using the same fuel components but where ignition improvers and HVO were added to increase the CN to 52. The results indicated that, compared to conventional diffusion controlled combustion, PPC generated a more rapid heat release. With lower temperature combustion and increased fuel air mixing compared to conventional combustion, PPC produced also very low soot and NO emissions independent of the fuels tested. A drawback of PPC compared to conventional combustion was high HC and CO emissions, which also reduced the thermal efficiency. The pressure rise rate was high due to the fast combustion.