PODEn highlights advantages in soot reduction and renewable alternate fuels. This study uses a PODEn mixture (contains PODE3-6) from mass production as the oxygen fuel. Spray combustion of PODEn and diesel bend fuels in a constant volume vessel was studied using PLII-LEM and OH chemiluminescence. Several blend ratios are compared with pure diesel. It is found that 20% PODEn blended with diesel (P20) can effectively reduce the total soot. Significant soot reduction as over 70% lower than diesel case is observed in P30 combustion. The distribution of soot cloud of P30 is different with that of diesel, which indicates the high oxygen content in PODEn results in big differences in soot formation and oxidization process. However, OH images shows that the ignition positions of blend fuels have small differences, which indicates that low lend ratio does not have great impact on combustion control strategies.