The structure of a vehicle is capable of absorbing a significant amount of heat when exposed to hot climate conditions. 50-70% of this heat penetrates through the glazing and raises both the internal cabin air temperature and the interior trim surface temperature. When driving away, the air conditioning system has to be capable of removing this heat in a timely manner, such that the occupant’s time to comfort will be achieved in an acceptable period . When we reduce the amount of heat absorbed, the discomfort in the cabin can be reduced. A 1D/3D based integrated computational methodology is developed to evaluate the impact of vehicle orientation on cabin climate control system performance and human comfort in this paper. Additionally, effects of glazing material and blinds opening/closing are analyzed to access the occupant thermal comfort during initial and final time AC pull down test.