Alcohols are potential blending agents for use in compression ignition engines. This work experimentally and numerically investigates the use of n-butanol as a blending component for diesel fuel. Dodecane was selected as a surrogate for diesel fuel and various concentrations of n-butanol were added to study ignition characteristics. A skeletal mechanism for n-dodecane and n-butanol blends with 203 species was developed for numerical simulations. The mechanism was developed by combining a 106 species n-dodecane skeletal mechanism and a detailed mechanism for all the butanol isomers. The mixture mechanism was validated for various pressure, temperature and equivalence ratio using a homogeneous reactor model form CHEMKIN pro solver for neat base fuels (n-dodecane and butanol). A computational fluid dynamics (CFD) platform was used for validation of n-dodecane/butanol blends (5, 10 and 20% by vol.) by using the commercially CFD solver CONVERGE. Ignition delay times for different n-butanol/dodecane blends were measured using the ignition quality tester at KAUST (KR-IQT). The experiments were conducted at a pressure of 2.1 & 1.8 MPa, temperature ranging from 703-843K and global equivalence ratio of 0.85. The mixture mechanism showed good agreement with ignition delay data predicted from the homogeneous reactor model; however, several deviations were observed for ignition delays predicted using CFD compared to those measured in the KR-IQT. Key words: Mixture skeletal mechanism, IQT experiments, CHMENKIN pro, CONVERGE CFD simulation.