Electrified powertrains are gaining acceptance on the light duty vehicles, but their impact of medium and heavy duty vehicles are not well understood. There are several prototyping efforts funded by US DOE in demonstrating the benefits in certain vehicle segments, but a larger study including several types of trucks is needed to understand the impact of specific powertrain technologies. This study proposes the use of a fleet of 13 different vehicles from various class, vocation combinations. This will cover over 50% of the type of medium and heavy duty vehicles on US roads. The vehicles that enjoy the market share in each category is taken as the baseline. Their fuel consumption and performance is simulated in Autonomie. Equivalent vehicles with electrified powertrains are designed with the underlying principle of not compromising on cargo or performance. Several performance characteristics were identified for benchmarking based on the feedback from the industry. Start-stop hybrids, parallel pre transmission hybrids, series plug-in hybrids, battery electric vehicles, and fuel cell powered trucks are considered as the technology choices in this study. The paper explains the component sizing process followed for each powertrain, and examines the fuel saving potential of each one. An attempt is also made at quantifying the initial and operational cost impact of these vehicles.