Previous research has detailed contributing factors to thoracolumbar compression fracture injury risk during frontal impacts in motorsport drivers utilizing a nearly recumbent driving position (Katsuhara, Takahira, Hayashi, Kitagawa, & Yasuki, 2017a; Trammell, Weaver, & Bock, 2006; Troxel, Melvin, Begeman, & Grimm, 2006). This type of injury is very rare for upright seated motorsport drivers. While numerous improvements have been made to the National Association for Stock Car Auto Racing, Incorporated (NASCAR®) driver restraint system since 2000, two instances of lumbar compression fractures have occurred during frontal impacts. This study explores the influence of initial driver position and seat ramp design on thoracolumbar loading during frontal motorsport impacts. Quasi-static component testing, dynamic component testing, an instrumented driver fit check, a seat ramp angle survey, and sled testing were conducted to provide computational finite element (FE) model inputs and serve as validation tests. Upright magnetic resonance imaging (MRI) was conducted with a driver to visualize vertebral body locations with respect to the driver seat. The Toyota Total Human Model for Safety (THUMS) was used in four unique seat ramp angles in two different postures, for a total of eight THUMS seated configurations. Each of the eight configurations were then subjected to 20 simulations using a latin hypercube (LHD) sample space for a total of 160 simulations.