In this paper, the turbulent flow induced by a production side-view mirror assembled on a full-scale production truck is simulated using a compressible detached eddy simulation (DES) approach. The truck configuration consists of a compartment and trailer. Due to the large size of the truck and the complexity of the geometry, some simplifications are applied in the simulation. A purpose of this work is to investigate whether the simplifications are valid to obtain the reasonable properties of the flow near the mirror. A simplification is to use the symmetric boundary condition on the symmetry plane of the truck configuration. Half of the configuration is therefore simulated. The computational results with this half configuration are compared with those with the entire configuration. Furthermore, the configuration is simplified in two ways. The first way is to remain the key exterior components of the truck body while removing the small gaps and structures. In the other simplification, the trailer is further simplified and the wheels, which are under the trailer, are removed. This simplification is derived from the assumption that the downstream flow near the trailer has limited effect on the flow near the mirror. To prove this assumption, the flow field computed from the two simplified configurations are compared. The A-pillar introduces the turbulence as well. Its influence on the development of the turbulence flow from the mirror is analyzed. The frequency spectra of the surface pressure on the window, which is located downstream of the mirror, are studied. The dominant sources of the hydrodynamic and acoustic pressure in the turbulent flow are addressed.