Upper frame deflection of automobile doors is a key design attribute that influences structural integrity and door seal performance as related to NVH. This is a critical customer quality perception attribute and is a key enabler to ensure wind noise performance is acceptable. This paper provides an overview of two simulation methodologies to predict upper door frame deflection. Traditional, simplified simulation approach using point loads is presented along with its limitations and is compared to a new method that uses CFD tools to accurately estimate aerodynamic loads on body panels at various vehicle speeds and wind directions. This Fluid Structure Interaction (FSI) simulation procedure passively couples structural and CFD flow solvers to generate accurate door deflection data. The details of the methodology are presented along with results and correlation to experimental data from the wind tunnel.