Introduction: The automotive industry is facing several significant challenges that go far beyond the design and manufacturing of automobile products. Connected-, autonomous-, and electric vehicles, smart cities, the uberization and the sharing economy all present challenges in a fast-changing environment the automotive industry must adapt to. Cars no longer are just standalone systems, but become constituent systems (CS) in larger System of Systems (SoS) connect. This is reflected in several vehicle-to-everything (V2X) acronyms that have emerged such as vehicle-to-vehicle (V2V), vehicle-to-infrastructure (V2I), and vehicle-to-grid (V2G) expressions. System of Systems are defined systems of interest whose elements (constituent systems) are managerially and/or operationally independent systems. This interoperating and/or integrated collection of constituent systems usually produce results unachievable by the individual systems alone, for example the use of car batteries as virtual power plants. This paper will (1) discuss automotive challenges the industry is currently facing, (2) provide an introduction into System of Systems Engineering (SoS), (3) provide examples and case studies of successful SoSE, and (4) make recommendations on how to address the automotive challenges applying SoSE.