This paper presents the results of study on sensitivity of serious injury outcome for drivers involved in nearside car to car (C2C) collisions, especially at intersection. In total, 865 intersection C2C crashes (NASS-CDS CY 2004-2014) are analysed in detail to determine the injury level outcome based on different crash factors, such as delta-v, age, gender, striking vehicle types, impact locations (F,Y,P,Z,B-regions based on CDC codes), amount of compartment intrusion and impact angle. A higher number of serious to fatal injuries (57%) occurred in the Y-region when compared to other impact locations. Additionally, a higher number of serious to fatal injuries (60%) occurred when the direction of impact is 10 o'clock. A Multi-variate logistic regression test is performed to predict the MAIS3+ injuries using lateral delta-v, age (<60/>60 years), belt usage (yes/no), number of events (single/multi), intrusion (<30cm/>30cm), and direction of impact (9/10 o'clock). It is found that direction of impact is significant (p<0.05) parameter and 10 o clock impact has more influence than 9 o'clock impact. A sensitivity analysis of serious injuries is performed with respect to lateral delta-v based on logistic regression equation. The probability of serious injury increases more than 2 times when the angle of impact changes from 9 to 10 o'clock. However, the increase in probability of serious injury when the lateral delta-v changes from change 25 to 30 kph (equivalent to 50 to 60kph impact velocity of struck vehicle) is less than that of the change due to angle of impact. The above physical phenomena real world accident results were also verified with barrier to car FE simulations. After the introduction of existing IIHS and SINCAP crash performance tests, modern vehicles are becoming safer. However, this study reveals that there is a room for further improvement to reduce serious injuries of occupants in side impact crashes. It can be achieved by proper selection and combination of important parameters (such as, impact angle, delta-v and location of impact) should be considered for future crash tests configurations.