The optimal design of vehicle NVH performance plays an important role in Vehicle research and development. However, the unbalance of propeller shaft has a great influence on the vehicle NVH performance. Analysis of unbalanced propeller shaft concentrates mainly on single propeller shaft at present. But, the distance of gearbox and final drive is relatively far in heavy truck, and the power is transmitted by multiple propeller shafts, so the coupling phenomenon of the unbalance on single propeller shaft will occurs. Coupling phenomenon of unbalance could worsen vehicle NVH performance. The main cause of vehicle NVH performance and the forces on propeller shaft support bearing was analyzed in this paper, such as the characteristics of multiple propeller shafts arrangement, phase angle of propeller shafts and the location and phase of unbalance. A rigid-flexible coupled model of three propeller shafts was set up. The simulations for propeller shaft system are presented, what shows that vehicle NVH performance could be improved by the reasonable arrangement of propeller shaft and the reasonable distribution of the unbalance.