This study presents a comparative analysis of seat and suspension parameters on a system level to achieve optimum ride comfort for the occupant. A lumped-parameter full-vehicle ride model with five occupants is used and a low amplitude pulse signal is provided as the road disturbance input. The peak vertical displacement and acceleration of the occupant’s head are used as measures of ride comfort. Using a design of experiments approach, the most critical seat cushion, seat structure and suspension parameters and their interactions affecting the ride comfort are determined. An optimum combination of parameters to achieve minimum peak vertical displacement of the occupant’s head is identified using a response surface methodology.