Since interior noise has a strong effect on vehicle salability, it is particularly important to be able to estimate noise levels accurately by means of simulation at the design stage. The use of sensitivity analysis makes it easy to determine how the analytical model should be modified or the structure optimized for the purpose of reducting vibration and noise of the structural-acoustic systems.The present work focused on a structural-acoustic coupling problem. As the coefficient matrices of a coupled structural-acoustic system are not symmetrical, the conventional orthogonality conditions obtained in structural dynamics generally do not hold true for the coupled system. To overcome this problem, the orthogonality and normalization conditions of a coupled system were derived by us. In this paper, our sensitivity analysis methods are applied to an interior noise problem of a cabin model. It will be shown how a sensitivity analysis process is performed, and how vibration and noise can be reduced.