A step in the development of advanced regenerative life support systems is to produce simulation models to guide experimentation and hardware development. This paper discuses the development of detailed simulation models of water reclamation processors using the ASPEN PLUS™ simulation program. Individual models have been developed for Vapor Compression Distillation (VCD), Vapor Phase Catalytic Ammonia Removal (VPCAR) and Supercritical Water Oxidation (SCWO). This paper outlines the methodology which is used to complete this work and discusses the insights which are gained by this type of model development. A discussion of how modeling predictions are used to direct future work in modeling and experimentation is also presented.The initial set of modeled processors were VCD, VPCAR, and SCWO. Future work will cover the modeling of other processors. These models will be linked to form subsystem level models, and evaluations will be performed on various configurations. A parallel path of hardware development will also be pursued. Innovative hardware design and development will be facilitated though the use of these advanced models. The subsystem level models (see figure 1) will allow for the development of processors which operate in intimately integrated subsystems.