The issue of pressurization is a complex and controversial one involving many engineering design variables. There are among the molten carbonate fuel cell (MCFC) developers and researchers differences in the relative perceived importance of these variables in the MCFC power plant systems determined to be of interest. These variables significantly affect MCFC system economics and commercial viability. While developing at pressure at this time may not be necessary to commercialize the MCFC, there are potential benefits of operating MCFC's at pressure. In this paper, the authors identify the advantages and disadvantages of operating the MCFC at pressure. Potential problems are discussed. The large and small power plant system implications of operating at pressure are qualified. Some recommendations are made. The overall goal of this paper is to create interest and motivate research in the area.