The Dynamic Isotope Power System (DIPS) Demonstration Program is currently focused on the development of a standardized 2.5-kWe portable generator for multiple applications on the lunar or Martian surface. An optimum system configuration has been developed for the 2.5-kWe DIPS module that provides a system with a radiator area which is small and manageable without significantly impacting the system mass, efficiency, and technological risk. The 2.5-kWe DIPS module configuration was developed based on a systematic series of studies. Initially, technology breakpoints in the DIPS component and subsystem designs were identified. Based on the technology assessments, the maximum design temperature for the system was selected and various system and subsystem configurations were evaluated. Finally, the subsystem and system designs for the selected configuration were optimized using a detailed system design optimization computer code.