The fatigue strength of spot welds in a multi-spot-welded structure is one of the key issues of concern for achieving structural durability and optimum design in automobile industry. In this study, a global-local fatigue life prediction method is proposed to predict the fatigue life of spot welds in multi-spot-welded structures. In this method, the remote stress-strain field away from the spot-welds, calculated from a global coarse finite element model, is assumed to be acceptable, and is used to recover the stress-strain information of the spot-welds. To improve the accuracy of the remote stress-strain field, an “equivalent” spot weld element is also proposed. The method makes it feasible to predict the fatigue life of spot welds without constructing a detailed finite element model for each spot weld. The method will help reduce finite element model size and save time.