A model has been developed for quantitative examination of the integrated operation of a lunar base power system, employing regenerative fuel cell technology, which would lead to incorporation into a lunar base life support system. The model employs methods developed for technology and system trade studies of the Life Support System configuration for the National Aeronautics and Space Administration (NASA). This paper describes the power system and its influence on life support while comparing various technologies, including pressurized gas storage and cryogenic storage, and different operation conditions. Based on preliminary assumptions, the mass, power, and thermal requirement estimates are made at the level of major components. The relative mass contribution and energy requirements of the components in various configurations are presented. The described interactions between power and life support include direct influence, such as water and oxygen storage, and indirect influence, through reliability and maintenance considerations.