A test has been completed at NASA's Marshall Space Flight Center (MSFC) to evaluate the latest Water Recovery and Management (WRM) system and Waste Management (WM) urinal design for the United States On-Orbit Segment (USOS) of the International Space Station (ISS) with higher fidelity hardware and integration than has been achieved in previous integrated tests. Potable and urine reclamation processors were integrated with waste water generation equipment and successfully operated for a total of 116 days to evaluate the impacts of changes made as a result of the redesign from Space Station Freedom (SSF) to the ISS. This testing marked the first occasion in which the WRM was automated at the system level, allowing for evaluation of the hardware performance under ISS operating conditions. It was also the first time a “flight-like” Process Control Water Quality Monitor (PCWQM) and a WM urinal were tested in an integrated system. Overall, the hardware showed no adverse effects in performance as a result of the redesign to the ISS configuration or system level automated control. This paper summarizes the test objectives, system design, test activities and protocols, significant results, anomalies and major lessons learned.