The incidence of decompression sickness (DCS) in space appears to be less than that predicted to occur on the basis of ground based altitude chamber trials. Our current work uses six hours of chair rest adynamia and likewise produces fewer gas bubbles when compared to standing in a cross over study. Mild exercise during oxygen prebreathe is also very efficacious in reducing DCS and bubble formation (measured by Doppler ultrasound). The effect is postulated to be the result of the alteration in the populations of tissue micronuclei such that the radii are reduced. Surface tension then becomes too great for bubble growth from the existing inert gas partial pressures.