Fatigue analysis using finite element models of a full vehicle body structure subjected to proving ground durability loads is a very complex task. The current paper presents an analytical procedure for fatigue life predictions of full body structures based on a time-domain approach. The paper addresses those situations where this kind of analysis is necessary. It also discusses the major factors (e.g., stress equivalencing procedure, cycle counting method, event lumping and load interactions) which affect fatigue life predictions in the procedure. A comparison study is conducted which explores the combination of these factors favorable for realistic fatigue life prediction. The concepts are demonstrated using a body system model of production size.