Separated flows and subsequent formation of shear layers are important fluid processes which play a dominant role in numerous engineering applications. Prediction of this fluid process is an important element in the design and analysis of highspeed vehicles and, ultimately, in the performance and trajectory analysis. The prediction methodology used in the current study includes the numerical solution of the Navier-Stokes equations on a multi-block grid system. Several turbulence models are used to investigate their performance for compressible, turbulent, separated and shear layer flows. The computational results are compared to available experimental data.