Ribbed floor panels have been widely applied in vehicle body structures to reduce interior noise. The conventional approach to evaluate ribbed floor panel designs is to compare natural frequencies and local stiffness. However, this approach may not result in the desired outcome of the reduction in radiated noise.Designing a “quiet” floor panel requires minimizing the total radiated noise resulting from vibration of the floor panel. In this study, the objective of ribbed floor panel design is to reduce the total radiated sound power by optimizing the rib patterns. A parametric study was conducted first to understand the effects of rib design parameters such as rib height, width, orientation, and density. Next, a finite element model of a simplified body structure with ribbed floor panel was built and analyzed. The structural vibration profile was generated using MSCINastran, and integrated with the acoustic boundary element model. Then, a boundary element analysis was performed to predict the total radiated sound power of the floor panel. With this approach, different ribbed floor panel designs were evaluated without hardware being built. The optimized ribbed floor panel design showed a significant reduction of the total sound power in the desired frequency range.