The establishment of a human-tended lunar base requires an autonomous bioregenerative life support system. Bioregeneration within a Lunar Engineered Closed/Controlled EcoSystem (LECCES) can be realized by integrating humans, plants, animals, and waste treatment subsystems. This integration incorporates physical/chemical and biological waste treatment processes that minimize resupply requirements from Earth. A LECCES top-level system integration model is developed based on human metabolic massflow requirements. The proposed model is presented and its components are discussed.