This study examines the current state of the art in rodent habitats as well as the next generation of rodent habitats currently under development at NASAs Ames Research Center. Space Shuttle missions are currently limited in duration to just over two weeks. In contrast to this, future life science missions aboard the Space Station may last months or even years. This will make resource conservation and utilization critical issues in the development of rodent habitats for extended microgravity missions. Emphasis is placed on defining rodent requirements for extended space flights of up to 90 days, and on improving habitability and extending the useful performance life of rodent habitats.