One of the thrusts of the Advanced Integrated Fuel System (AIFS) initiative, sponsored by the Fuels Branch of the Aero and Propulsion Power Directorate at Wright Laboratories (WL/POSF) with partial funding from the United States Navy, is to realize the potential improvements in aircraft thermal management systems due to the 100 degrees F increase in fuel heat sink capacity of JP-8+100 fuel. This paper summarizes the conceptual design and top-level trade studies conducted by Northrop Grumman Corporation (NGC) under an AIFS contract. These studies examined the air vehicle-level payoffs of JP-8+100 fuel applied to the (1) F/A-18C/D (representing an existing fleet aircraft), (2) F/A-18E/F (representing an aircraft currently under development), and (3) a more-electric aircraft/subsystem integration technology (MEA/SUIT) configured version of an F/A-18 (representing a future aircraft). The objectives and approaches of these studies are presented. The results of these studies, in terms of the thermal management system benefits and their impact on mission or performance enhancement, are also provided.