Deformation of the hub, rotor, and the wheel results in lateral run-out of the rotor. The effect of contact surface variations and bolt forces on the deformation is investigated. It is analytically shown that the run-out due to deformation is caused primarily due to the radial and circumferential moments generated in the hub and the rotor due to bolt tightening. Case studies illustrate the interaction between hub, rotor, and the wheel for various surface conditions. Design guidelines are provided to reduce rotor run-out.