This paper presents a numerical analysis of the effect of weld induced residual stress on the fatigue behavior of a T-joint. The thick-section T-joint contained 18 individual weld passes and was subjected to fully-reversed, zero-maximum, and zero-minimum fatigue cycling. The effect of the residual stress was demonstrated by comparing the result with and without residual stress. It was concluded that the local fatigue parameters (mean stress, alternating stress, and stress ratio) at the suspected crack initiation site were changed significantly by the residual stresses when the applied stress were other than fully reversed. In addition, the effect of the stress concentration at the weld was more significant that the effect of the residual stress for the applied fatigue loads levels that were considered. The analysis method presented can be used to assess weldment design and process variables.