This paper compares four potential water treatment systems in the context of their applicability to a Mars transit vehicle mission. The systems selected for evaluation are the International Space Station system, a JSC bioreactor-based system, the vapor phase catalytic ammonia removal system, and the direct osmotic concentration system. All systems are evaluated on the basis of their applicability for use in the context of the Mars Reference Mission. Each system is evaluated on the basis of mass equivalency. The results of this analysis indicate that there is effectively no difference between the International Space Station system and the JSC bioreactor configurations. However, the vapor phase catalytic ammonia removal and the direct osmotic concentration systems offer a significantly lower mass equivalency (approximately 1/7 the ISS or bioreactor systems).