With the continuing success of the Space Transportation System, attention is currently being focused upon the assessment of the ways in which a crewperson's capabilities can be utilized. The purpose of this paper is to identify candidate crew roles in space, as these roles relate to crew-payload interaction. Additionally, the advantages of the crew's presence in space will be optimized as designers increasingly depend on man's inherent capabilities and integrate them in the operating system. Design guidelines and considerations will be reviewed and specific advantages of utilizing man versus machine will be addressed, as well as man/machine function allocation, crew restraint systems, and displays and controls.